One of those teams is local league outfit Sporting de Lamego from the Viseu region who will travel south to play SC Olhanense on 24 September.
The other four Algarve teams remaining in the competition must travel, with Louletano facing a long trip to the Azores to play SC Praiense. Other ties are:
GD União Torcatense (Guimarães) v. Lusitano VRSA; SC Espinho (Aveiro) v. Moncarapachense; Amora FC (Setúbal) v. SC Farense. All games to be played over the weekend 23/24 September.