The 27-year-old American was the only player in the field to break par on the Sunday at Winged Foot Golf Club, and did it in style with a three under par 67.
That gave DeChambeau a six under total, making him the only player to finish in red numbers for the week, with Matthew Wolff finishing six shots adrift in second.
Starting the day two behind Wolff, the 21-year-old seeking to become the youngest U.S. Open winner for over a century, DeChambeau wasted little time reeling in his playing partner.
DeChambeau is just the third player after Jack Nicklaus and Tiger Woods to win an NCAA individual title, the U.S. Amateur title and a U.S. Open.
Asked at the trophy presentation what it meant to be in such exalted company, DeChambeau said: “It’s just an honour. I don’t know what else to say.
“It’s been a lot of hard work. Mr Nicklaus has been always awesome to me. He gave me a sponsor’s invite. Tiger has always been great to me.”