Of the 594 new confirmed cases of infection, 280 were registered in the Lisbon and Tagus Valley region, which represents almost half of the total.
According to the DGS epidemiological bulletin, the number of patients hospitalised in wards continues to decline, with four less than on Tuesday, for a total of 233.
As for admissions to intensive care units, there is one more patient admitted (53) than the day before.
The death occurred in Madeira.
The data also show that there was a reversal in active cases of infection, with an increase of 176 more, for a total of 22,347.
In the last 24 hours, 417 more people were reported recovered, bringing the total to 807,065 since the start of the pandemic.
Health authorities have 762 more contacts on surveillance today than on Tuesday, bringing the total to 20,613.
According to the latest data from the DGS, Portugal has more than five million people vaccinated (5,078,712) against Covid-19, of which 1,572,242 are already immunised with the two doses.
The North region now has 185 new SARS-CoV-2 infections, totalling 339,644 cases of infection and 5,354 deaths since the pandemic began.
In the Lisbon and Tagus Valley region, another 280 cases have been reported, totalling 319,901 cases and 7,211 deaths attributed to Covid-19.
In the Centre region 64 more cases were reported, accumulating 119,636 infections and 3,021 deaths.
In Alentejo 13 more cases were reported, totalling 30,116 infections and 971 deaths.
In the Algarve region, the bulletin reveals that 18 more infections were registered, accumulating 22,190 cases and 363 deaths.
The Autonomous Region of Madeira recorded one death and 18 new infections, accounting for 9,660 cases and 69 deaths due to Covid-19.
The Azores recorded 26 new cases today, accounting for 5,287 cases and 33 deaths since the start of the pandemic, according to the DGS.
The regional authorities of the Azores and Madeira release their data daily, which may not coincide with the information released in the bulletin.
The new coronavirus has already infected at least 461,540 women and 384,534 men in Portugal, DGS data show, according to which there are 360 cases of unknown gender, which are under investigation as this information is not provided automatically.
Of the total number of fatalities, 8,940 were men and 8,082 women.
The highest number of deaths continues to be concentrated among the elderly over 80 years of age, followed by the age group between 70 and 79 years.
The transmissibility index (Rt) of the SARS-Cov-2 coronavirus continues to rise, standing today at 1.07, while the incidence of cases of infection per 100,000 inhabitants in the past 14 days increased to 57.8.
The Covid-19 pandemic has caused at least 3,487,457 deaths worldwide, resulting from more than 167.7 million cases of infection, according to an assessment made by the French agency AFP.