Benfica and Sporting look to be favourites to make the last four but FC Porto and SC Braga need to win and rely on other results going in their favour.
Moreirense and Rio Ave are also in contention. The final will also be played at the Algarve Stadium on Sunday 29 January.
Of added interest is that the three games have been chosen to trial the VARs (Video Assistant Referees) where contentious decisions will be reviewed as in rugby.
All three games kick-off at 8.45pm and tickets at 15/10/5 euros can be purchased online at: www.blueticket.pt