The Institute of Materials at the University of Aveiro created injectable systems to improve the efficacy and retention of cells at injury sites.

In cell therapy systems, small platforms that transport cells, known as cell delivery systems, are essential to ensure cells reach the intended site and remain there long enough to exert their therapeutic effect.

In their study published today, the researchers describe how they synthesised microneedles from polyoxometalate hybrids using a ‘bottom-up’ approach, resulting in their spontaneous formation.

A press release explains that the microscopic structures possess a quasi-one-dimensional geometry, much like small needles. This design gives them a high surface-to-volume ratio—about twice that of a spherical delivery system of the same volume—which promotes cell adhesion.

The elongated shape helps the cells remain at the site of administration and increases the efficacy of cell-based therapies, he adds.

According to the researchers, laboratory tests “demonstrated 95% cytocompatibility and the cells’ ability to adhere spontaneously to the microneedles”.

“The platforms also allow for magnetic functionalisation of the surface to control the movement and orientation of the structures in bioengineered tissues,” he adds.

The study is authored by Marta Maciel, José Silvares, Tiago Correia, Carlos Mendonça, Ana Martins, Eduardo Silva, Nuno Silva, Filipa Sousa and João Mano, researchers at the Aveiro Institute of Materials (CICECO), one of the University of Aveiro’s research units.